The main side effects of clomiphene citrate

Chemical structure

clomid clomiphene citrate – refers to the anti-estrogen drugs, which are assigned to women during the treatment course anovulatory infertility. It also has in mind when talking about non-steroidal ovulation stimulants in the field of clinical medicine. Efficacy is achieved by its interaction with estrogen receptors, and, most commonly occurs antagonistically in various tissues, such as the hypothalamus and pituitary gland, the endometrium or ovary, vagina or cervix. Clomid – is a selective estrogen receptor modulator for, which is characterized by agonistic and antagonistic properties. From the chemical point of view it has the formula: 2- [4- (2-chloro-1,2-difenilvinil) phenoxy] triethylamine dihydrogen citrate.

Historical reference

As a therapeutic drug Clomid for infertility in the United States began to use back in the early 70s. Today it is already known around the world and produced by pharmaceutical companies under the names Clomid, serofen, sepafar, omifin, pergotaym, gonafen, duinum, klostil, AYou and klostilbegit. More info

Mode of action (according to the manufacturer’s data)

Medicine antiestrogen character. It works by binding to estrogen receptors which are found in the ovaries and the hypothalamus. Process metabolized in the liver. The drug is excreted with bile, is subject to enterohepatic recirculation. A natural way out of the body for 5-7 days. At low concentrations there may be enhancement of production of gonadotropins (e.g., prolactin, LH and FSH), and promotes ovulation stimulation. If estrogens in humans is contained in insufficient quantities, Clomiphene citrate has little estrogenic effect, while excessive content – antiestrogen. The drug reduces circulating estrogen increases the production of gonadotropins and with considerable dosage may suspend the production of gonadotropins. He is not peculiar progestogen and androgen activity.

Clomiphene citrate Properties

When Clomid is used by men, it performs the role of an anti-estrogen in part, so it can be used as a tool against a number of side effects such as aromatization AAS, gynecomastia, or the delay in the removal of water. It also increases the production of follicle stimulating and luteinizing hormones which are responsible for increasing testosterone levels. It is recommended to be taken with chorionic gonadotropin and tamoxifen after “rate”, because at this time of endogenous testosterone is reduced and if it does not pick up in time, there will be a significant decrease in body weight and muscle strength. The fact is that without androgens (including testosterone and free) cortisol begins to dominate the process of protein synthesis that occurs in muscle tissue, and there is catabolism, which could destroy much of the muscle gained during “the course.” Please note that all connections triphenylethylene character (toremifene citrate, tamoxifen citrate, clomiphene citrate), basically have estrogenic effects on the liver. This means that they have the strength and blocking estrogen in all body tissues, and estrogen function in the other areas. It is important to adjust the level of production of “good” and “bad” cholesterol. When using steroids, certainly there is a danger to the failure of the cardiovascular system, which is exacerbated by the receiving aromatase inhibitors. The course of treatment Clomid can contribute to stop gynecomastia, as well as to ensure the balance of harmful and beneficial cholesterol.

A feature of the drug is also a stop feedback of a negative character between estrogen on the hypothalamic-pituitary-testes, which increases the synthesis of gonadotropins (LH and FSH). Similarly, it is similar to the action of tamoxifen and tsiklofenilom. The greater N is, the greater will be the testosterone. This effect has a core value of the program after the FCT “course.”

Clomiphene citrate Application

Reception (for men):

Athletes take it on 50-100-150mg day (it depends on the circuit FCT). Duration “rate” is 30 days, which is enough to bring content to the desired level of testosterone. In this case it mainly acts component recovery circuit.

Reception (for women):

It is used to treat challenging courses related to ovulation disorders. Among women – athletes Clomid is used to reduce the mass of adipose tissue on the hips for better quality and appearance of the muscles.

Side effects of clomiphene citrate

In most cases, clomiphene citrate tolerated without problems. Sometimes, however, can exhibit such side effects as headache or dizziness, depression or fatigue, anxiety or insomnia, blurred vision, nausea or vomiting, cystic ovarian enlargement or dysmenorrhea, pollakiuria or polyuria, multiple pregnancy, tides or weight gain, pain in the abdomen or in the chest, the testicles (in men), hyperthermia and reversible hair loss, and skin reactions of allergic nature. Read more

Indications for drug use

Anovulatory infertility, dysfunctional bleeding in the uterus, amenorrhea (disgonadotropnaya form secondary, postkontratseptivnaya), galactorrhea (which arose against the backdrop of a tumor in the pituitary gland), polycystic ovarian syndrome (Stein – Leventhal) syndrome Chiari – Frommelya, androgen deficiency, oligospermia, as well as the need to diagnose disorders of the pituitary gonadotrophic function.

Contraindications for medical use

Individual high sensitivity, severe renal failure, uterine bleeding undiagnosed etiology, ovarian cysts, tumors, or pituitary insufficiency, pregnancy (and suspected it).